Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review.
نویسندگان
چکیده
Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the 'PKC hypothesis' of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.
منابع مشابه
Sphingosine kinase activation mediates ischemic preconditioning in murine heart.
BACKGROUND Phosphorylation of sphingosine by sphingosine kinase (SK) is the rate-limiting step in the cellular synthesis of sphingosine 1-phosphate (S1P). The monoganglioside GM1, which stimulates SK, is cardioprotective in part through increased generation of S1P that protects myocytes by diverse mechanisms. Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic ...
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ورودعنوان ژورنال:
- Cardiovascular research
دوره 40 1 شماره
صفحات -
تاریخ انتشار 1998